Urine biomarker
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摘要:疾病的早期诊断是医学最重要的问题.早期诊断可以给医生有效治疗的机会.尿液不像血液那样受身体稳态效应的控制,能够汇集大量的疾病相关变化,因此尿液能够更好地反映早期微小的变化,是生物标志物的更好体液来源.动物模型研究证明了尿液作为早期标志物来源的潜力.部分研究利用了临床样本,但是很多研究没有认真考虑可以影响尿液的大量各种混杂因素.我们提出如果疾病引起的变化足够大、足够独特的时候,才能利用疾病对健康人群分组的方式发现疾病尿液标志物.如果能利用同一个人的前后对照,可以解决大量混杂影响因素的对照问题,让尿液标志物更早地用于临床.在没有疾病前样本的情况下,还可以利用一个病人对多个健康对照样本的方法找到疾病线索.本文将总结现代尿液生物标志物理论的发生发展和现状,并展望未来的发展前景.Abstract:Early diagnosis of disease is the most important problem in medicine.Early diagnosis can give doctors a chance to treat the disease effectively.Urine, unlike blood, is not subject to homeostasis controls and is able to accumulate many disease-related changes.Therefore it can reflect early and small changes and is a better biomarker sources.Animal model studies have demonstrated the potential of urine as a source of early markers.There have been some studies using clinical samples, but many have not taken into account the large variety of confounders that can affect urine.If the changes caused by the disease are large enough and unique enough, urine markers of disease can be found by comparing disease group to healthy control group.If urine samples from the same person before and after the disease can be compared, it can minimize the effects of confounding factors.In this way, urine biomarker may be able to be translated into clinical practice earlier.In the absence of samples before the disease, clues to disease can also be found by using the patient compare to multiple healthy control samples as a group.This review will summarize the start, development, current situation and perspectives of modern urine biomarker theory.
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Key words:
- urine/
- biomarker/
- disease/
- early detection
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[1] CANNON W B. Physiological regulation of normal states: some tentative postulates concerning biological homeostatics[M]. Paris: Editions Medicales, 1926 [2] 高友鹤. 尿液有可能成为生物标志物的金矿吗? [J]. 中国科学: 生命科学, 2013, 43(8): 708 [3] GAO Y H. Roadmap to the urine biomarker era[J]. MOJ Proteomics & Bioinformatics, 2014, 1(1): 00005 [4] WEI J, GAO Y H. Early disease biomarkers in urine proteomes of animal models[J]. Expert Rev Proteomics, 2021, 7: 1 [5] 张亚萌, 衡姊琦, 魏静, 等. 晚期肺癌患者药物治疗前后尿蛋白质组的变化[EB/OL]. (2020-03-20) [2022-04-18].http://www.paper.edu.cn/releasepaper/content/202003-251 [6] WU J Q, ZHANG J, WEI J, et al. Urinary biomarker discovery in gliomas using mass spectrometry-based clinical proteomics[J]. Chinese Neurosurgical Journal, 2020, 6: 11 [7] 赵晨阳, 魏利龙, 魏静, 等. 利用一对多尿液蛋白质组比较为发热待查提供线索[EB/OL]. ( 2022-03-09) [2022-04-18]. http://biotech.chinaxiv.org/abs/202203.00025 [8] WU J Q, GAO Y H. Physiological conditions can be reflected in human urine proteome and metabolome[J]. Expert Review of Proteomics, 2015, 12(6): 623 [9] AN M X, GAO Y H. Urinary biomarkers of brain diseases[J]. Genomics, Proteomics & Bioinformatics, 2015, 13(6): 345 [10] 郇宇航, 秦伟伟, 高友鹤. 尿液蛋白生物标志物验证时要考虑的因素[J]. 中国科学: 生命科学, 2018, 48(2): 171 [11] 衡姊琦, 高友鹤. AOM DSS诱导炎症引起的小鼠结直肠癌模型尿液蛋白质组的研究[EB/OL]. (2021-12-01)[2022-04-18]. http://biotech.chinaxiv.org/abs/202112.00007 [12] 王云龙, 高友鹤. 探究DEN诱导大鼠肝癌-炎癌模型中尿液蛋白质组的变化[EB/OL]. (2022-01-09)[2022-04-18]. http://biotech.chinaxiv.org/user/search.htm?serverID=2 [13] 孟文书, 高友鹤. 易卒中高血压(SHRSP)大鼠尿液蛋白质组学变化的研究[EB/OL]. (2022-02-28) [2022-04-18]. http://biotech.chinaxiv.org/user/search.htm?serverID=2 [14] 华元瑞, 孟文书, 魏静, 等. 动脉粥样硬化ApoE-/-小鼠模型尿液蛋白质组变化探究[EB/OL]. (2021-04-08)[2022-04-18]. http://eprint.las.ac.cn/abs/202104.00023 [15] 衡姊琦, 赵晨阳, 高友鹤. 荷瘤与切除肿瘤小鼠尿液蛋白质组的比较[EB/OL]. (2022-03-14)[2022-04-18]. http://chinaxiv.org/user/search.htm [16] 王云龙, 高友鹤. 观察免疫过程中大鼠尿蛋白组的动态变化[EB/OL]. (2022-04-04)[2022-04-18]. http://chinaxiv.org/user/search.htm [17] 潘宣圳, 刘永涛, 鲍艺今, 等. 流感疫苗接种前后尿液蛋白质组变化[EB/OL]. (2022-03-09)[2022-04-18]. http://chinaxiv.org/user/search.htm [18] 汤抒璇, 高友鹤.大鼠妊娠过程的尿蛋白组变化[EB/OL]. (2022-04-01) [2022-04-18]. http://chinaxiv.org/user/search.htm [19] 鲍艺今, 成祥, 朱玲玲, 等. 大鼠急性低氧模型尿液蛋白质组的变化[EB/OL]. (2022-03-03)[2022-04-18]. http://chinaxiv.org/user/search.htm [20] 汤抒璇, 郇宇航, 高友鹤, 等. 尿蛋白质组学预测艾司西酞普兰药效[EB/OL]. (2022-03-11) [2022-04-18]. http://chinaxiv.org/user/search.htm [21] JI Y, HEBBRING S, ZHU H, et al. Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics[J]. Clinical Pharmacology & Therapeutics, 2011, 89(1): 97 [22] 华元瑞, 郭晓甜, 高友鹤. 通过尿蛋白质组发现无表型基因修饰动物的改变[EB/OL]. (2021-12-15)[2022-04-18]. http://chinaxiv.org/user/search.htm [23] JIA L L, LIU X J, LIU L, et al. Urimem, a membrane that can store urinary proteins simply and economically, makes the large-scale storage of clinical samples possible[J]. Science China: Life Sciences, 2014, 57(3): 336
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